SEMAX Peptide – User Manual & Dosage Protocol Guide

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH), primarily investigated for its neuroprotective, cognitive-enhancing, and nootropic effects.

Research Applications:

• Enhancing memory, learning, and focus
• Supporting neuroprotection and recovery from neurological stress
• Promoting anxiolytic and mood-stabilizing effects
• Potential cognitive support in experimental neurological research

Disclaimer: Semax is for research and experimental use only. It is not FDA-approved for therapeutic use. Consult a qualified healthcare professional before use.

Lyophilized Powder – Freeze-dried Semax for reconstitution

Nasal Spray Solution – Ready-to-use intranasal administration

Injection Solution – Subcutaneous (SC) or intramuscular (IM) solution after reconstitution

Semax is believed to act via:

• Modulation of neurotransmitter systems, including dopaminergic, serotonergic, and glutamatergic pathways
• Supporting brain-derived neurotrophic factor (BDNF) expression, enhancing neuronal plasticity
• Promoting antioxidant and neuroprotective effects

Effects are primarily observed in preclinical and experimental research protocols.

Administration

Subcutaneous (SC) Injection – Typical Dose: 300–600 µg | Frequency: 1–2× per day | Notes: Administer consistently for best results

Intranasal Spray – Typical Dose: 300–600 µg per dose | Frequency: 2–3× per day | Notes: Apply evenly between nostrils

Intramuscular (IM) Injection – Typical Dose: 300–600 µg | Frequency: 1–2× per day | Notes: Often used for systemic research applications

Cycle Protocol (Investigational)

Initial Phase (5–7 days) – Dose: Lower end of dosing range | Notes: Assess tolerance

Therapeutic Phase (2–4 weeks) – Dose: 300–600 µg 1–2× per day | Notes: Optimal cognitive and neuroprotective effects

Rest Period (1–2 weeks) – Dose: None | Notes: Allows system to reset before next cycle

Experimental cycles may be repeated 2–4 times per year, depending on research goals.

Supplies Needed:

• Sterile bacteriostatic water
• Sterile syringe
• Alcohol swabs

Steps:

1. Clean vial top with alcohol swab.
2. Add the desired volume of bacteriostatic water (e.g., 1 mg peptide + 1 mL water → 1 mg/mL solution).
3. Swirl gently to dissolve; do not shake.
4. Store refrigerated (2–8°C).
5. Use within 2–4 weeks; discard if cloudy or discolored.

Subcutaneous Injection (SC)

1. Select a clean injection site (abdomen, thigh, upper arm).
2. Clean with alcohol swab.
3. Insert needle at 45° angle.
4. Inject slowly; apply gentle pressure afterward.
5. Rotate injection sites weekly.

Intramuscular Injection (IM)

1. Select clean muscle site (deltoid, glute, thigh).
2. Clean with alcohol swab.
3. Insert needle at 90° angle and inject slowly.
4. Apply gentle pressure afterward.

Intranasal Administration

1. Use recommended dose (usually 300–600 µg) per nostril.
2. Tilt head slightly back and spray evenly in both nostrils.
3. Avoid rinsing nostrils immediately for optimal absorption.

Storage InformationLyophilized Powder – Storage: Cool, dry place | Shelf Life: Up to 12 months

Reconstituted Solution – Storage: Refrigerate 2–8°C | Shelf Life: 2–4 weeks

Nasal Spray – Storage: Refrigerate or room temperature per manufacturer | Shelf Life: 1–2 months

Discard solution if cloudy, discolored, or contains particulates.

• Not recommended for pregnant or breastfeeding women
• Avoid if allergic to peptides
• Mild side effects: nasal irritation, headache, or injection site redness
• Discontinue if severe adverse reactions occur
• Keep out of reach of children

Human clinical data are limited; effects are investigational.

Weekly Cycle ScheduleWeek 1 – Dose: 300 µg SC/IM/Nasal 1× per day | Notes: Initial tolerance phase

Week 2–4 – Dose: 300–600 µg SC/IM/Nasal 1–2× per day | Notes: Therapeutic phase

Week 5+ – Dose: Rest 1–2 weeks | Notes: Reset before next cycle

• Diagrams of SC and IM injection sites (abdomen, thigh, arm, deltoid, glute)
• Step-by-step nasal spray guide
• Step-by-step reconstitution guide
• Safety icons for handling, storage, and injections