MOTS-C Peptide – User Manual & Dosage Protocol Guide

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a mitochondrial-derived peptide investigated for its role in metabolic regulation, energy homeostasis, and cellular health.

Research Applications:

• Enhancing metabolic function and glucose homeostasis
• Supporting mitochondrial efficiency and cellular energy
• Promoting fat metabolism and exercise performance
• Potential anti-aging and longevity effects

Disclaimer: MOTS-C peptide is for research and experimental use only. It is not FDA-approved for therapeutic use. Consult a qualified healthcare professional before use.

Product FormLyophilized Powder – Freeze-dried MOTS-C for reconstitution

Injection Solution – Subcutaneous (SC) or intramuscular (IM) solution after reconstitution

Oral Capsules – Experimental use; bioavailability may vary

MOTS-C acts by:

• Modulating mitochondrial metabolism and energy production
• Enhancing AMPK signaling, promoting fat oxidation and insulin sensitivity
• Supporting cellular homeostasis and stress resistance
• Improving glucose uptake in muscle and other tissues

Effects are primarily observed in preclinical research and experimental protocols.

Administration

Subcutaneous (SC) Injection – Typical Dose: 5–15 mg | Frequency: 1–3× per day | Notes: Targeted metabolic and energy support

Intramuscular (IM) Injection – Typical Dose: 5–15 mg | Frequency: 1–2× per day | Notes: Localized or systemic administration

Oral Capsules – Typical Dose: 5–10 mg | Frequency: Daily | Notes: Effects slower; bioavailability may be reduced

Cycle Protocol (Investigational)

Initial Phase (1–2 weeks) – Dose: Lower end of dose range | Notes: Assess tolerance and metabolic response

Therapeutic Phase (3–6 weeks) – Dose: Full dose range | Notes: Optimal metabolic and mitochondrial support

Rest Period (1–2 weeks) – Dose: None | Notes: Allows system to reset before next cycle

Experimental cycles may be repeated 2–4 times per year, depending on research goals.

Supplies Needed:

• Sterile bacteriostatic water
• Sterile syringe
• Alcohol swabs

Steps:

1. Clean vial top with alcohol swab.
2. Add the desired volume of bacteriostatic water (e.g., 10 mg peptide + 2 mL water → 5 mg/mL solution).
3. Swirl gently to dissolve; do not shake.
4. Store refrigerated (2–8°C).
5. Use within 2–4 weeks; discard if cloudy or discolored.

Subcutaneous Injection (SC)

1. Select a clean injection site (abdomen, thigh, or upper arm).
2. Clean the site with alcohol swab.
3. Insert needle at 45° angle.
4. Inject slowly; apply gentle pressure afterward.
5. Rotate injection sites to avoid tissue irritation.

Intramuscular Injection (IM)

1. Select clean muscle site (deltoid, glute, thigh).
2. Clean with alcohol swab.
3. Insert needle at 90° angle and inject slowly.
4. Apply gentle pressure afterward.

Oral Capsules

• Take on an empty stomach for better absorption.
• Daily consistent dosing is recommended.

Storage InformationLyophilized Powder – Storage: Cool, dry place | Shelf Life: Up to 12 months

Reconstituted Solution – Storage: Refrigerate 2–8°C | Shelf Life: 2–4 weeks

Oral Capsules – Storage: Room temperature, dry place | Shelf Life: 12 months

Discard solution if cloudy, discolored, or containing particulates.

• Not recommended for pregnant or breastfeeding women
• Avoid if allergic to peptides
• Mild side effects may include injection site irritation or transient fatigue
• Discontinue if severe adverse reactions occur
• Keep out of reach of children

Human clinical data are limited; effects are investigational.

Weekly Cycle ScheduleWeek 1–2 – Dose: 5–10 mg SC/IM, 1× per day | Notes: Initial tolerance phase

Week 3–4 – Dose: 10–15 mg SC/IM, 1–2× per day | Notes: Therapeutic phase

Week 5–6 – Dose: 10–15 mg SC/IM, 2–3× per day | Notes: Full effect cycle

Week 7+ – Dose: Rest 1–2 weeks | Notes: Reset before next cycle

• Diagrams of SC and IM injection sites (abdomen, thigh, arm, deltoid, glute)
• Step-by-step reconstitution guide
• Safety icons for handling, storage, and injections