Melanotan II Peptide – User Manual & Dosage Protocol Guide

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Product Overview

Melanotan II (MT-II) is a synthetic analog of α-MSH (alpha-melanocyte-stimulating hormone) studied in research for its effects on melanin production and melanocortin receptor activation.

Research Applications

  • Skin pigmentation and UV response research
  • Melanocortin receptor activity studies
  • Dermatological and cosmetic modeling
  • Photoprotection pathway investigation

Disclaimer: Melanotan II is for research and experimental use only and is not FDA-approved for therapeutic or cosmetic medical use.

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Forms Available

Lyophilized Powder

Freeze-dried peptide for reconstitution

Reconstituted Solution

Subcutaneous research injection after preparation

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Mechanism of Action (Research)

Melanotan II is studied for its ability to:

  • Activate melanocortin receptors (primarily MC1R)
  • Stimulate melanin synthesis in melanocytes
  • Increase pigmentation response in UV exposure models
  • Influence appetite and other melanocortin pathways in experimental systems

Observed effects are primarily from preclinical and investigational settings.

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Dosage Protocol (Investigational Reference)

There is no approved human dosage. The following reflects commonly cited research patterns only.

Subcutaneous (SC) Administration

Typical range: 0.25–1 mg

Frequency: Once daily (initiation)

Notes: Begin low to assess response

Maintenance Research

Typical range: 0.5–1 mg

Frequency: 2–3× weekly

Notes: Pigmentation maintenance models

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 Cycle Framework (Research Models)

Initiation Phase

Duration: 1–2 weeks

Purpose: Gradual response evaluation

Active Phase

Duration: 2–6 weeks

Purpose: Pigmentation and receptor studies

Maintenance Phase

Duration: As designed

Purpose: Intermittent administration

Rest Period

Duration: 1–2 weeks

Purpose: Reset between study cycles

Cycle length varies by study design and endpoints.

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Reconstitution Instructions

Supplies

  • Sterile bacteriostatic water
  • Sterile syringe
  • Alcohol swabs

General Procedure

  1. Clean vial stopper with alcohol.
  2. Add bacteriostatic water to achieve desired concentration.
  • Example: 10 mg vial + 1 mL → 10 mg/mL
  1. Swirl gently to dissolve (do not shake).
  2. Refrigerate at 2–8°C after reconstitution.
  3. Use within 2–4 weeks or per research protocol.
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Administration Guidelines (Research Handling)

Subcutaneous Injection Model

  • Common sites: abdomen, thigh, upper arm
  • Clean site prior to administration
  • Inject slowly and rotate sites
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Storage Guidelines

Lyophilized Powder

Storage: Cool, dry environment

Shelf life: Up to 12 months

Reconstituted Solution

Storage: Refrigerated (2–8°C)

Shelf life: 2–4 weeks

Protect From

Light, heat, and contamination

Discard if the solution becomes cloudy or discolored.

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Safety & Handling

  • Research use only
  • Not for therapeutic application
  • Possible research observations: flushing, nausea, injection-site irritation
  • Maintain sterile technique
  • Keep out of reach of children

Human safety profile outside controlled research is not established.

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Quick Reference

Peptide: Melanotan II
Category: Skin Health / Pigmentation Research
Delivery: Subcutaneous research model
Typical Investigational Range: 0.25–1 mg
Cycle: 2–6 week study designs
Storage: Refrigerated after reconstitution