CAGRILINTIDE Peptide – User Manual & Dosage Protocol Guide

Cagrilintide is a long-acting amylin analogue peptide designed to regulate appetite and support weight management. It mimics the hormone amylin, which is naturally co-secreted with insulin, helping to:

• Reduce hunger and caloric intake
• Slow gastric emptying for prolonged satiety
• Support weight management and metabolic health

Disclaimer: Cagrilintide is investigational and not FDA-approved. Use is for research or experimental purposes only. Consult a qualified healthcare professional before use.

Lyophilized Powder: Freeze-dried peptide for reconstitution

Injection Solution: Subcutaneous solution after reconstitution

Cagrilintide works by:

• Activating amylin receptors (AMYR) to suppress appetite
• Activating calcitonin receptors (CTR) to slow gastric emptying
• Supporting blood glucose stabilization and weight management

Effects: Appetite suppression, satiety, delayed gastric emptying, and potential metabolic benefits.

Administration

Subcutaneous Injection (SC)

• Typical Dose: 0.3–2.4 mg weekly
• Frequency: Once weekly

Notes: Start at a lower dose for tolerance; gradual titration is recommended.

Titration Example (from clinical protocols)

• Week 1–2: 0.3 mg once weekly
• Week 3–4: 0.6 mg once weekly
• Week 5–6: 1.2 mg once weekly
• Week 7–8: 1.8 mg once weekly
• Week 9+: 2.4 mg weekly (target maintenance dose)

Titration helps minimize gastrointestinal side effects such as nausea and vomiting.

Supplies Needed:

• Sterile bacteriostatic water
• Sterile syringe
• Alcohol swabs

Steps:

1. Clean vial with alcohol swab.
2. Add desired volume of bacteriostatic water (e.g., 1 mg peptide + 1 mL water → 1 mg/mL solution).
3. Gently swirl to dissolve; do not shake.
4. Store refrigerated (2–8°C).

Use within 2–4 weeks; discard if cloudy or discolored.

Subcutaneous Injection (SC)

1. Select clean injection site (abdomen, thigh, or upper arm).
2. Clean site with alcohol swab.
3. Insert needle at 45° angle.
4. Inject slowly and steadily.
5. Apply gentle pressure; rotate injection sites weekly.

Note: Cagrilintide is administered once weekly.

Storage Information

Lyophilized Powder

• Storage: Cool, dry place
• Shelf Life: Up to 12 months

Reconstituted Solution

• Storage: Refrigerate at 2–8°C
• Shelf Life: 2–4 weeks

Important:
Do not freeze the reconstituted solution. Discard if cloudy or discolored.

• Not for pregnant or breastfeeding women
• Avoid use if allergic to peptides
• Possible side effects: nausea, vomiting, mild gastrointestinal discomfort
• Discontinue if severe adverse reactions occur
• Keep out of reach of children

Cagrilintide is investigational; long-term safety in humans is under evaluation.

Weekly Dosing Schedule

Week 1–2

• Dose: 0.3 mg per week
• Notes: Initial low-dose titration

Week 3–4

• Dose: 0.6 mg per week
• Notes: Gradual escalation

Week 5–6

• Dose: 1.2 mg per week
• Notes: Intermediate dose

Week 7–8

• Dose: 1.8 mg per week
• Notes: High dose

Week 9+

• Dose: 2.4 mg per week
• Notes: Target maintenance dose
  

• Include SC injection site diagrams (abdomen, thigh, upper arm)
• Step-by-step reconstitution guide
• Safety icons for refrigeration, handling, and caution